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Prop 65: Listing of N,N-dimethyl-p-toluidine
(May 2014)

California’s Office of Environmental Health Hazard Assessment (OEHHA) is adding N,N-dimethyl-p-toluidine to the list of chemicals known to the state to cause cancer under Proposition 65. The National Toxicology Program (NTP) formally identified N,N-dimethyl-p-toluidine as a known carcinogen in 2012. As a result, OEHHA has determined that the criteria for listing the chemical under the authoritative bodies mechanism have been met. The listing is effective May 2, 2014.


Chemical CAS No. Endpoints Listing Mechanism
N,N-Dimethyl-p-toluidine 99-97-8 Cancer Authoritative Body (NTP)


N,N-dimethyl-p-toluidine is commonly used in the manufacture of dental materials and bone cements, in industrial glues, in artificial fingernail preparations, and as an accelerator in the curing of methyl methacrylate monomers. It is also used as an intermediate in dye and pesticide synthesis.

OEHHA’s determination is based on evidence in a 2012 National Toxicology Program report, “Toxicology and Carcinogenesis Studies of N, N-Dimethyl-p-Toluidine (CAS No. 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies),” that concluded the chemical causes cancer. The report found that N,N-dimethyl-p-toluidine caused cancers of the liver and nose in male and female rats, cancer of the liver in male and female mice, and cancers of the lung and forestomach in female mice. Thyroid gland tumors in male rats may also have been related to exposure to the chemical.

OEHHA’s Notice of Intent to List N,N-dimethyl-p-toluidine can be found
here.

For more information, please Contact TSG.
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