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Prop 65: Notice of Intent to List Hydrogen Cyanide and Cyanide Salts (May 2013)

California’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals hydrogen cyanide and cyanide salts as known to the state to cause reproductive toxicity (male reproductive toxicity endpoint) under Proposition 65. Hydrogen cyanide and cyanide salts are commonly used in mining, metallurgy, manufacturing, photography, rodenticide products, and are components of tobacco smoke.

A chemical is listed under Proposition 65 when two conditions are met:

1.  An authoritative body formally identifies the chemical as causing reproductive toxicity (Section 25306(d)).

2. The evidence considered by the authoritative body meets the sufficient criteria contained in the regulations (Section 25306(g)).

OEHHA has determined that hydrogen cyanide and cyanide salts meet the criteria for listing under Proposition 65 based on evaluations by EPA and the National Toxicology Program (NTP). EPA’s and NTP’s report on hydrogen cyanide and cyanide salts show that the chemicals cause statistically significant male reproductive effects in rats and mice, which increased in severity in a dose-dependent manner. These effects include decreased epididymis, cauda epididymis, and testes weight and decreased sperm parameters. In addition, EPA’s Toxicological Review document (U.S. EPA, 2010b) demonstrates the adverse effects of cyanide on the function of thyroid glands, which causes hypothyroidism leading to male reproductive damage both during development and in adult animals. Based on these findings, OEHHA concludes that hydrogen cyanide and cyanide salts cause reproductive toxicity in males and meet the criteria for Proposition 65 listing.

OEHHA asked for public comment on the listing notice which ended on April 22, 2013. Public comment is available for viewing
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