Prop 65: Listing of Four Chemicals Effective April 18, 2014
California’s Office of Environmental Health Hazard Assessment (OEHHA) is adding pentosan polysulfate sodium, pioglitazone, triamterene and pulegone to the Proposition 65 list of chemicals known to the state to cause cancer. The listing is effective as of April 18, 2014.
The four chemicals are being added to the Prop 65 list based on the California Labor Code mechanism, which stipulates that certain substances identified by the International Agency for Research on Cancer (IARC) be listed as known to cause cancer under Proposition 65. In reviewing the four chemicals, OEHHA has determined that each meet the requirements for listing.
|Chemical||CAS No.||Toxicological Endpoints||Listing Mechanism|
|Pentosan polysulfate sodium||--------||Cancer||Labor Code|
IARC concluded that pioglitazone can be classified as “probably carcinogenic to humans” in Group 2A. Pentosan polysulfate sodium, triamterene and pulegone were classified as “possibly carcinogenic to humans” in group 2B. IARC came to these conclusions based on each chemical’s level of carcinogenicity in experimental animals. More information on the carcinogenicity classifications used by IARC can be found here.
Details on the listing of pentosan polysulfate sodium, pioglitazone and triamterene can be found here.
Details on the listing of pulegone can be found here.
For more information, please Contact TSG.