Prop 65: Delisting of Five Chemicals Effective April 4, 2014
(April 2014)

The California Office of Health Hazard Assessment (OEHHA) has removed n-butyl glycidyl ether, diglycidyl ether, phenyl glycidyl ether, methyl isopropyl ketone and α-methyl styrene from the Proposition 65 list of chemicals known to the state to cause reproductive toxicity. The delisting of these chemicals is effective on April 4, 2014.

Chemical CAS Number Basis for TLV
n-Butyl glycidyl ether 2426-08-6 Male reproductive toxicity (“reproductive damage”)
Diglycidyl ether 2238-07-5 Male reproductive toxicity (“male reproductive damage”)
Phenyl glycidyl ether 122-60-1 Male reproductive toxicity (“testicular damage”)
Methyl isopropyl ketone 563-80-4 Developmental toxicity (“embryo/fetal damage”)
α-Methyl styrene 98-83-9 Female reproductive toxicity (“female reproductive damage”)










The five chemicals were originally added to the Proposition 65 list on the Labor Code listing mechanism, which incorporates the federal Hazard Communication Standard (HCS). Before 2012, which is when the chemicals were listed, the HCS specifically referred to the American Conference of Governmental Industrial Hygienists (ACGIH) list of Threshold Limit Values (TLVs) and “Subpart Z” of the federal regulations as definitive sources for the identification of chemical hazards. An amendment to the HCS in March 2012 removed references to TLVs as definitive evidence that a chemical is hazardous. Consequently, the five chemicals were referred by OEHHA to the Reproductive Toxicant Identification Committee (DARTIC) for review.

DARTIC evaluated scientific data covering the three major toxicological endpoints: developmental, male reproductive and female reproductive toxicity. DARTIC concluded that the five chemicals have not been clearly shown, through scientifically valid testing according to generally accepted principles, to cause reproductive toxicity and should be removed from the list.

Detailed background information, data and summary reports from DARTIC can be found
here.

For more information, please Contact TSG.


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